Liver Function And Metabolism Practice Test Practice Tests

Question 1

Which of the following blood vessels provides the majority (approximately 70%) of blood supply to the liver?

Accepted Answer

B. Portal vein

Answer

A. Hepatic artery

Answer

C. Hepatic vein

Answer

D. Inferior vena cava

Question 2

The liver's lymphatic drainage primarily flows into which of the following lymph node groups?

Accepted Answer

C. Celiac nodes

Answer

A. Axillary nodes

Answer

B. Inguinal nodes

Answer

D. Mesenteric nodes

Question 3

The liver's regenerative capacity is unlimited, allowing it to fully recover from any degree of damage.

Accepted Answer

True

Answer

False

Question 4

Which enzyme is responsible for conjugating bilirubin with glucuronic acid in the liver, making it water-soluble?

Accepted Answer

A. UGT1A1

Answer

B. Heme oxygenase

Answer

C. Biliverdin reductase

Answer

D. Cytochrome P450

Question 5

Which of the following conditions can impair the excretion of conjugated bilirubin into bile?

Answer

A. Viral hepatitis

Answer

B. Cholestasis of pregnancy

Answer

C. Dubin-Johnson syndrome

Answer

D. Hemolytic anemia

Answer

E. Gilbert's syndrome

Question 6

Define portal hypertension and list two common complications associated with it.

Accepted Answer

Portal hypertension is defined as an elevation of portal blood pressure >5 mm Hg. Two common complications include ascites and esophageal varices.

Question 7

Which of the following is NOT primarily synthesized by the liver?

Accepted Answer

Apo B48

Answer

Albumin

Answer

Coagulation factors

Answer

Angiotensinogen

Question 8

Gluconeogenesis is the breakdown of glycogen into glucose.

Accepted Answer

True

Answer

False

Question 9

Name three substrates used by the liver for gluconeogenesis.

Accepted Answer

Amino acids, lactate, glycerol

Question 10

Which of the following proteins are synthesized by the liver?

Answer

Albumin

Answer

C-reactive protein

Answer

Factor VIII

Answer

Transferrin

Question 11

Taurine is synthesized from which two amino acids in the presence of Vitamin B6?

Accepted Answer

Methionine and Cysteine

Answer

Alanine and Glycine

Answer

Glutamine and Aspartate

Answer

Serine and Threonine

Question 12

Taurine is an essential amino acid for adults.

Accepted Answer

True

Answer

False

Question 13

What is the role of taurine in relation to bile acids?

Accepted Answer

Bile acid conjugation

Question 14

Which of the following lipoproteins is primarily responsible for transporting triglycerides synthesized by the liver to peripheral tissues?

Accepted Answer

VLDL

Answer

Chylomicrons

Answer

LDL

Answer

HDL

Question 15

Which enzyme system is primarily responsible for Phase I drug metabolism in the liver?

Accepted Answer

Cytochrome P450 system

Answer

UDP-glucuronosyltransferase

Answer

Sulfotransferase

Answer

Glutathione S-transferase

Question 16

In acetaminophen toxicity, increased NAPQI production leads to glutathione depletion, resulting in damage to hepatocyte cell membranes.

Accepted Answer

True

Answer

False

Question 17

Which enzyme catalyzes the rate-limiting step in bilirubin production?

Accepted Answer

Heme oxygenase

Answer

Biliverdin reductase

Answer

Uridine-diphosphoglucuronate glucuronosyltransferase (UGT)

Answer

Glutathione S-transferase

Question 18

Which transporter is responsible for the excretion of conjugated bilirubin into bile?

Accepted Answer

MRP2 (ABCC2)

Answer

OATP1B1

Answer

BCRP

Answer

MDR1

Question 19

What is the primary cause of jaundice in newborns?

Accepted Answer

UGT1A1 deficiency

Question 20

Which of the following are common complications of portal hypertension?

Answer

Esophageal varices

Answer

Ascites

Answer

Hepatic encephalopathy

Answer

Pulmonary fibrosis

Answer

Renal cell carcinoma

Liver Function And Metabolism Practice Test Practice Tests

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Liver Function and Metabolism Practice Test

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